Artigos Científicos

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Advocacy

Bayer, Angela M.; Hunter, Gabrielle C.; Gilman, Robert H.; Carpio, Juan G. Cornejo del; Naquira, Cesar; Bern, Caryn; Levy, Michael Z. Chagas disease, migration and community settlement patterns in Arequipa, Peru. PLoS Neglected Tropical Diseases, vol.3, issue 12, e567. 2009.
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Carod-Artal, F.J; Gascon, J. Chagas disease and stroke. Lancet Neurol 2010; 9: 533–42
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Castillo-Riquelme, Marianela; Guhl, Felipe; Turriago, Brenda; Pinto, Nestor; Rosas, Fernando; Martinez, Mônica Florez; Fox-Rushby, Julia; Davies, Clive; Campbell-Lendrum, Diarmid. The cost of preventing and treating Chagas disease in Colombia. In: PLOS, Vol.2, issue 11, e336. Nov 2008.
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Crager SE, Price M. Prizes and parasites: incentive models for addressing chagas disease. J Law Med Ethics. 2009 Summer;37(2):292-304.
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Guerri-Guttenberg, Roberto A; Ciannameo, Anna; Girolamo, Chiara D; Milei, José J. Chagas disease: an emerging public health problem in Italy? Le Infezioni in Medicina,n.1,5-13,2009.
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Oprea, L; Braunack-Mayer, A; Gericke, CA; Ethical issues in funding research and development of drugs for neglected tropical diseases. J. Med. Ethics 2009; 35;310-314
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Rassi Jr. A; Rassi, A; Marin-Neto, J.A. Chagas disease. Lancet 2010; 375: 1388–402
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Schmunis, G.A.; The Globalization of Chagas disease. In: ISBT Science Series, nº2: 6-11. 2007
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Villa, Luis; Morote, Silvia; Bernal, Oscar; Bulla, Daniel; Albajar-Vinas, Pedro; Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. In: Rio de Janeiro: Mem. Inst. Oswaldo Cruz, Vol.102(Suppl. 1): 87-93. 2007.
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Weir, Erica. Chagas disease: hidden affliction and visible neglect. In: CMAJ, 174(8), p.1096. Apr. 2006.
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Yadon, Zaida E.; Schmunis, Gabriel A. Congenital Chagas disease: estimating the potential risk in the United States. Am. J. Trop. Med. Hyg., 81(6), 2009, pp. 927–933.
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Tratamento

Andrade, Ana Lucia S. Sgambatti de; Zicker, Fabio; Oliveira, Renato Maurício de; Silva, Simonne Almeida e; Luquetti, Alejandro. Travassos, Luiz R.; Almeida, Igor C.; Andrade, Soraya S. de; Andrade, João Guimarães de; Martelli, Celina M. T. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma Cruzi infection. In: Lancet, 348: 1407-13. 1996.
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Barr, S. C.; Warner, K. L.; Kornreic, B. G.; Piscitelli, J.; Wolfe, A.; Benet, L.; McKerrow, J. H. A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection by Trypanosoma Cruzi. In: Antimicrobial Agents and Chemotherapy, p. 5160-5161. Dec. 2005.
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Batista, Ronan; Humberto, Jorge Luiz; Chiari, Egler; Oliveira, Alaíde Braga de; Synthesis and trypanocidal activity of ent-kaurane glycosides. In: ScienceDirect. 2006.
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Bern, Caryn; Montgomery, Susan P.; Herwaldt, Barbara L.; Rassi Jr, Anis; Marin-Neto, Jose Antonio; Dantas, Roberto O.; Maguire, James H.; Acquatella, Harry; Morillo, Carlos; Kirchhoff, Louis V.; Gilman, Robert H.; Reyes, Pedro A.; Salvatella, Roberto; Moore, Anne C. Evaluation and Treatment of Chagas Disease in the United States. In: JAMA, Vol. 298, nº18. November 14, 2007.
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Brak K, Doyle PS, McKerrow JH, Ellman JA. Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc. 2008 May 21;130(20):6404-10
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Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit. PLoS Negl Trop Dis. 2009;3(2):e372
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Corrales, Milagros; Cardozo, Rubén; Segura, Maria Asunción; Urbina, Julio A.; Basombrío, Miguel Angel. Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas’ Disease. In: Antimicrobial Agents and Chemotherapy, Vol. 49, nº 4, p.1556-1560. Apr 2005.
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Coura, José Rodrigues; Castro, Solange L. de; A Critical Review on Chagas Disease Chemotherapy. In: Rio de Janeiro: Mem. Inst. Oswaldo Cruz, Vol. 97(3): 3-24. Jan. 2002.
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Dias, João Carlos Pinto; The Treatment of Chagas disease (South American Trypanosomiasis). In: Annals of Internal Medicine, nº144: 772-774. 2006.
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Doyle PS, Zhou YM, Engel JC, McKerrow JH. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9
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Duschak, Vilma G.; Couto, Alicia S. An Insight on Targets and Patented Drugs for Chemotherapy of Chagas Disease. In: Recent Patents on Anti-Infective Drug Discovery, 2, 19-51. 2007.
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Engel JC, Doyle PS, Hsieh I, McKerrow JH. Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection. J Exp Med. 1998 Aug 17;188(4):725-34.
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Franco-Paredes C, Bottazzi ME, Hotez PJ (2009). The Unfinished Public Health Agenda of Chagas Disease in the Era of Globalization. PLoS Negl Trop Dis 3(7): e470.
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Garcia, Simone; Ramos, Carolina O.; Senra, Juliana F. V.; Vilas-Boas, Fabio; Rodrigues, Mauricio M.; Campos-de-Carvalho, Antonio C.; Ribeiro-dos-Santos, Ricardo; Soares, Milena B. P. Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations. In: Antimicrobial Agents and Chemotherapy, Vol. 49, nº4: 1521-1528. Apr 2005.
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Jannin, Jean; Villa, Luis. An Overview of Chagas disease treatment. Rio de Janeiro: Mem. Inst. Oswaldo Cruz. 2007.
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Kraus JM, Verlinde CL, Karimi M, Lepesheva GI, Gelb MH, Buckner FS. Corrections to Rational Modification of a Candidate Cancer Drug for Use against Chagas Disease. J Med Chem. 2009 Jun 2. [Epub ahead of print] No abstract available.
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Lannes-Vieira, Joseli; Araújo-Jorge, Tania C. de; Soeiro, Maria de Nazaré Correia; Gadelha, Paulo; Corrêa-Oliveira, Rodrigo; The Centennial of the Discovery of the Chagas Disease: Facing the Current Challenges (2010). PLoS Negl Trop Dis 4(6): e645.
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Ribeiro I, Sevcsik AM, Alves F, Diap G, Don R, Harhay MO, Chang S, Pecoul B. New, Improved Treatments for Chagas Disease: From the R&D Pipeline to the Patients.  In PLoS Negl Trop Dis 3(7): e484.
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Senkovich, Olga; Bhatia, Vandanajay; Garg, Nisha; Chattopadhyay, Debasish. Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas’ Disease. In: Antimicrobial Agents and Chemotherapy, vol. 49, nº8: 3234-3238. Aug. 2005.
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Silva, J.J.N.; Osakabe, A.L.; Pavanelli, W.R.; Silva, J.S.; Franco, D.W. In vitro and in vivo antiproliferative and trypanocidal activities of ruthenium NO donors. In: British Journal of Pharmacology, p.1-10. 2007.
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Souza, Elen M. de; Oliveira, Gabriel M.; Boykin, David W.; Kumar, Arvind; Hu, Qiyue; Soeiro, Maria de Nazaré C. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. In: Journal of Antimicrobial Chemotherapy, nº58: 610-614. 2006.
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Suasnábar, Diana Fabbro de; Arias, Enrique; Streiger, Mirtha; Piacenza, Maria; Ingaramo, Mônica; Del Barco, Mônica; Amicone, Noberto. Evolutive Behavior Towards Cardiomyopathy of Treated (nifurtimox or benznidazole) and untreated chronic chagasic patients. In: Rev. Inst. Med. Trop. S. Paulo, Vol. 42, nº2. Apr. 2000.
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Villar, Juan Carlos; Desenlaces clínicos de sujetos con infección crónica por Trypanosoma cruzi tratados o no con agentes tripanocidas. Un metaanálisis de estudios observacionales. In: MEDUNAB. 2002.
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Viotti, Rodolfo; Vigliano, Carlos; Armenti, Héctor; Segura, Elsa. Treatment of chronic Chagas’ disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up. In: American Heart Journal, Vol. 127, p.151-62. 1994.
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Yun O, Lima MA, Ellman T, Chambi W, Castillo S, et al. (2009). Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in Honduras, Guatemala and Bolivia: 10-Year Experience of Médecins Sans Frontières. PLoS Negl Trop Dis 3(7): e488.
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Diagnóstico

Cardinal, Marta V.; Reithinger; Richard; Gurtler, Ricardo E.; Use of an Immunochromatographic Dipstick Test for Rapid Detection of Trypanosoma cruzi in Sera from Animal Reservoir Hosts. In: Journal of Clinical Microbiology, Vol. 44, nº8, p. 3005-3007. Aug 2006.
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Deborggraeve S, Coronado X, Solari A, Zulantay I, Apt W, Mertens P, Laurent T, Leclipteux T, Stessens T, Dujardin JC, Herdewijn P, Büscher P. T. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for Diagnosis of Chagas Disease. PLoS Negl Trop Dis. 2009 Jun 2;3(6):e450.
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Médicos sem Fronteiras. International meeting: “New diagnostic tests are urgently needed to treat patients with Chagas disease”. In: Revista da Sociedade Brasileira de Medicina Tropical, 41(3): 315-319. Jun. 2008.
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